![]() ![]() Google Patents Method of purification of polymeric medical device materials using continuous soxhlet extractionĭownload PDF Info Publication number US6790318B2 US6790318B2 US10/260,449 US26044902A US6790318B2 US 6790318 B2 US6790318 B2 US 6790318B2 US 26044902 A US26044902 A US 26044902A US 6790318 B2 US6790318 B2 US 6790318B2 Authority US United States Prior art keywords solvent extractor extraction polymeric materials lenses Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US6790318B2 - Method of purification of polymeric medical device materials using continuous soxhlet extraction I’m planning on running pentane in mine at atmosphere or only slightly vac assisted as it doesn’t need much help in terms of BP- should make for some very fast extractions- thimbles won’t be swapped so much as the whole material column will be changed out.US6790318B2 - Method of purification of polymeric medical device materials using continuous soxhlet extraction The design will be easily scaled up or down and be able to function under vac very simply and without worry of glass breakage. Now you will be pleased to hear that I am currently putting together a parts list for a massive 8x48” Soxhlet extractor made from stainless steel that will fit on top of a jacketed reactor. There is actually a paper from he olden times about vacuum soxhlets that describes how they are made, interesting read You will need to attach a vac hose to the top of the condenser and also make something called an elbulliator which is simply a capillary tube which sits below the surface level of your solvent in the boiling flask and helps keep boiling constant and prevents bumping. I have run numerous vacuum assisted soxhlet extractions, it’s really hard on the glass and often a small bump or vibration will cause breakage, esp on the cheaper glass that most of the decent sized soxhlets 1000-2000ml I have used are made from. Has anyone pulled a vacuum in a Soxhlet rig? I am having difficulty getting it to firm up.Īnybody put any thought to drawing a vacuum in a Soxhlet? I have thought about pulling a vacuum through the open end. The extract that I just made is super-terpinated. Recovery of the solvent is possible, via simple distillation. If you pay attention, you can gradually decrease the solvent level in the boiling flask, making post-processing faster. Not a big problem, unless you let the solvent get too low.ĭry material can actually make life easier, by holding solvent that you would otherwise have to remove later. The solvent volume in the boiling flask will gradually decrease, if you are using only the reflux to wet your sample. If your new sample is dry, it will absorb and hold some solvent. When placing a new sample, you might choose to add a small quantity of new solvent directly into the thimble. ![]() I have been using tongs, but it is sketchy, so want to research other choices. This has been a small stumbling block…it’s hot in there. Once you exhaust your sample, and desire to change out the thimble, you have to get it out of the extraction chamber. ![]() I have tried to minimize this possibility by packing cotton into the chamber. It is heavy, and could easily break the chamber wall, if dropped. Once one sample is exhausted (I usually see this around the 4th or 5th dump), I can replace it with fresh material. The Soxhlet extractor is a reflux setup, so clean fresh solvent is always hitting your sample. ![]() The nicest thing is the ability to really load up the solvent with extracted oil. Every sample is only 15-20 gms, so it does take a while to run a larger quantity. Therefore, I assume that small batch runs are its prime forte. I know that a bunch of you do industrial sized runs, and scaling these up is not normally done. It is simple, easy to run and it is exhaustive on the extraction. ![]()
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